Enteric fever in endemic areas of Indonesia: an increasing problem of resistance | Zendy

Mochammad Hatta | Zendy; Name Ratnawati | Zendy

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Enteric fever in endemic areas of Indonesia: an increasing problem of resistance

Author(s) -

Mochammad Hatta,

Name Ratnawati

Publication year - 2008

Publication title -

the journal of infection in developing countries

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 49

eISSN - 2036-6590

pISSN - 1972-2680

DOI - 10.3855/jidc.222

Subject(s) - typhoid fever , chloramphenicol , ampicillin , salmonella typhi , ciprofloxacin , medicine , outbreak , drug resistance , virology , antibiotics , salmonella , antibiotic resistance , intensive care medicine , microbiology and biotechnology , biology , bacteria , biochemistry , genetics , escherichia coli , gene

Reported levels of antibiotic resistance in Salmonella Typhi from South Sulawesi, Indonesia were very low (< 1%) before 2001 and chloramphenicol remained the treatment of choice. Since 2001 however resistance has been rising and in 2007 6.8% of isolates were resistant to all three first line drugs: Ampicillin, chloramphenicol and co-trimoxazole. Ciprofloxacin resistance is currently at 3.90 %. At the same time there has been an increase in the number of reported cases. This may be because of improved diagnostics or it may be a genuine outbreak of drug resistant S. Typhi. In conclusion drug resistant typhoid fever will become a serious problem in Indonesia in the future, requiring the use of expensive drugs for the treatment of typhoid. A concerted effort is needed by the medical services to implement reliable diagnosis so that treatment or vaccination can be used to control the spread of drug resistant typhoid fever.

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