Plasmodium falciparum malaria, bilateral sixth cranial nerve palsy and delayed cerebellar ataxia | Zendy

Vítor Duque | Zendy; Diana Seixas | Zendy; Conceição Ventura | Zendy; Saraiva da Cunha | Zendy; A MeliçoSilvestre | Zendy

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Plasmodium falciparum malaria, bilateral sixth cranial nerve palsy and delayed cerebellar ataxia

Author(s) -

Vítor Duque,

Diana Seixas,

Conceição Ventura,

Saraiva da Cunha,

A MeliçoSilvestre

Publication year - 2011

Publication title -

the journal of infection in developing countries

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 49

eISSN - 2036-6590

pISSN - 1972-2680

DOI - 10.3855/jidc.2177

Subject(s) - malaria , plasmodium falciparum , medicine , ataxia , parasitemia , cerebellar ataxia , palsy , quinine , doxycycline , surgery , pediatrics , immunology , pathology , biology , antibiotics , alternative medicine , psychiatry , microbiology and biotechnology

We describe the case of a 14-year-old Caucasian male, a resident in the Democratic Republic of the Congo, who was observed in Portugal with severe Plasmodium falciparum malaria with high-level parasitemia and severe thrombocytopenia. The course was complicated by bilateral sixth cranial nerve palsy during acute malaria, followed by the appearance of delayed cerebellar ataxia during the recovery phase. This occurred after successful treatment with quinine plus doxycycline over seven days. Different levels of thrombocytopenia and C-reactive protein were observed during both neurologic events in the presence of HRP-2 positive tests for Plasmodium falciparum antigen. The patient recovered completely after three months.

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