Moringa oleifera leaf extracts inhibit 6β-hydroxylation of testosterone by CYP3A4 | Zendy

Tsitsi Grace Monera | Zendy; Alan R. Wolfe | Zendy; Charles C. Maponga | Zendy; Leslie Z. Benet | Zendy; Joseph Guglielmo | Zendy

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Moringa oleifera leaf extracts inhibit 6β-hydroxylation of testosterone by CYP3A4

Author(s) -

Tsitsi Grace Monera,

Alan R. Wolfe,

Charles C. Maponga,

Leslie Z. Benet,

Joseph Guglielmo

Publication year - 2008

Publication title -

the journal of infection in developing countries

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 49

eISSN - 2036-6590

pISSN - 1972-2680

DOI - 10.3855/jidc.201

Subject(s) - moringa , cyp3a4 , traditional medicine , hydroxylation , microsome , ic50 , cytotoxicity , chemistry , metabolite , testosterone (patch) , pharmacology , enzyme , biochemistry , biology , in vitro , cytochrome p450 , medicine , endocrinology

Moringa oleifera is a tropical tree often used as a herbal medicine, including by people who test positive for HIV. Since herbal constituents may interact with drugs via inhibition of metabolizing enzymes, we investigated the effects of extracts of M. oleifera on the CYP3A4-mediated 6beta-hydroxylation of testosterone.

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