Tumorigenesis related to retroviral infections | Zendy

Maria Braoudaki | Zendy; Fotini TzortzatouStathopoulou | Zendy

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Tumorigenesis related to retroviral infections

Author(s) -

Maria Braoudaki,

Fotini TzortzatouStathopoulou

Publication year - 2011

Publication title -

the journal of infection in developing countries

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 49

eISSN - 2036-6590

pISSN - 1972-2680

DOI - 10.3855/jidc.1773

Subject(s) - virology , retrovirus , rous sarcoma virus , carcinogenesis , oncovirus , murine leukemia virus , virus , biology , leukemia , viral transformation , cancer , bovine leukemia virus , immunology , genetics

Retroviral infections are considered important risk factors for cancer development in humans since approximately 15-20% of cancer worldwide is caused by an infectious agent. This report discusses the most established oncogenic retroviruses, including human immunodeficiency virus (HIV), human T-cell leukemia virus (HTLV-1 and -2), Rous sarcoma virus (RSV), Abelson murine leukemia virus (A-MuLV), Moloney murine leukemia virus (M-MuLV), murine mammary tumor virus (MMTV), bovine leukemia virus, (BLV), Jaagsiekte sheep retrovirus (JSRV), and Friend spleen focus-forming virus (SFFV). The role of retroviruses as inducers of carcinogenesis, the mechanisms underlying oncogenic transformation, and the routes of transmission of several cancer-related retroviral infections are also described. Finally, the impact of cancer-related retroviral infections in the developing world is addressed. This review is an update of carcinogenesis caused by retroviral infections.

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