Anti-Trypanosoma cruzi activity, cytotoxicity and, chemical characterization of extracts from seeds of Lonchocarpus cultratus | Zendy

Aline Griebler | Zendy; Fernanda Weyand Banhuk | Zendy; Izabela Virginia Staffen | Zendy; Aline Antunes Maciel Bortoluzzi | Zendy; Thaís Soprani Ayala | Zendy; Rinaldo Ferreira Gandra | Zendy; Ivânia T.A. Schuquel | Zendy; Edson Antonio Alves da Silva | Zendy; Tereza Cristina Marinho Jorge | Zendy; Rafael Andrade Menolli | Zendy

Open Access

Anti-Trypanosoma cruzi activity, cytotoxicity and, chemical characterization of extracts from seeds of Lonchocarpus cultratus

Author(s) -

Aline Griebler,

Fernanda Weyand Banhuk,

Izabela Virginia Staffen,

Aline Antunes Maciel Bortoluzzi,

Thaís Soprani Ayala,

Rinaldo Ferreira Gandra,

Ivânia T.A. Schuquel,

Edson Antonio Alves da Silva,

Tereza Cristina Marinho Jorge,

Rafael Andrade Menolli

Publication year - 2021

Publication title -

the journal of infection in developing countries

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 49

eISSN - 2036-6590

pISSN - 1972-2680

DOI - 10.3855/jidc.12669

Subject(s) - trypanosoma cruzi , cytotoxicity , dichloromethane , chemistry , chagas disease , ic50 , trypanocidal agent , traditional medicine , amastigote , hemolysis , toxicity , in vitro , microbiology and biotechnology , biochemistry , biology , leishmania , immunology , trypanosoma brucei , medicine , parasite hosting , solvent , world wide web , computer science , gene , organic chemistry

Trypanosoma cruzi is the agent of Chagas' disease and affects approximately 6-8 million people worldwide. The search for new anti-T. cruzi drugs are relevant because only two drugs exist actually. The objective of this study was to investigate the effect of the extracts from the seeds of Lonchocarpus cultratus on T. cruzi, its cytotoxicity as well as to elucidate its chemical profile.

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