Salmonella enterica Serovars Typhi and Paratyphi A are avirulent in newborn and infant mice even when expressing virulence plasmid genes of Salmonella Typhimurium | Zendy

Javier Santander | Zendy; Roy Curtiss | Zendy

Open Access

Salmonella enterica Serovars Typhi and Paratyphi A are avirulent in newborn and infant mice even when expressing virulence plasmid genes of Salmonella Typhimurium

Author(s) -

Javier Santander,

Roy Curtiss

Publication year - 2010

Publication title -

the journal of infection in developing countries

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 49

eISSN - 2036-6590

pISSN - 1972-2680

DOI - 10.3855/jidc.1218

Subject(s) - virulence , microbiology and biotechnology , salmonella typhi , biology , salmonella , salmonella enterica , virology , serotype , plasmid , typhoid fever , bacteria , gene , escherichia coli , biochemistry , genetics

Salmonella enterica serovars Typhi and Paratyphi A are human host-restricted pathogens. Therefore, there is no small susceptible animal host that can be used to assess the virulence and safety of vaccine strains derived from these Salmonella serovars. However, infant mice have been used to evaluate virulence and colonization by another human host-restricted pathogen, Vibrio cholerae.

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