Assessing the role of the RND efflux pump in metronidazole resistance of Helicobacter pylori by RT-PCR assay | Zendy

Jalil Fallah Mehrabadi | Zendy; Mehrandokht Sirous | Zendy; Naser Ebrahimi Daryani | Zendy; Saeed Eshraghi | Zendy; Bahram Akbari | Zendy; Mohammad Hasan Shirazi | Zendy

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Assessing the role of the RND efflux pump in metronidazole resistance of Helicobacter pylori by RT-PCR assay

Author(s) -

Jalil Fallah Mehrabadi,

Mehrandokht Sirous,

Naser Ebrahimi Daryani,

Saeed Eshraghi,

Bahram Akbari,

Mohammad Hasan Shirazi

Publication year - 2010

Publication title -

the journal of infection in developing countries

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 49

eISSN - 2036-6590

pISSN - 1972-2680

DOI - 10.3855/jidc.1187

Subject(s) - efflux , helicobacter pylori , metronidazole , microbiology and biotechnology , biology , resistance (ecology) , antibiotics , genetics , ecology

Metronidazole is a significant antibiotic used for eradication of Helicobacter pylori infections and it is of notice that metronidazole-resistant clinical isolates have been found in high rates worldwide. While the RND family of efflux pumps plays a central role in drug resistance among Gram-negative bacteria, this is questionable for H. pylori.

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