Threshold value of the anti-HCV test in the diagnosis of HCV infection | Zendy

Özlem Kirişçi | Zendy; Ahmet Çalışkan | Zendy

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Threshold value of the anti-HCV test in the diagnosis of HCV infection

Author(s) -

Özlem Kirişçi,

Ahmet Çalışkan

Publication year - 2019

Publication title -

the journal of infection in developing countries

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 49

eISSN - 2036-6590

pISSN - 1972-2680

DOI - 10.3855/jidc.11657

Subject(s) - hepatitis c virus , gold standard (test) , medicine , receiver operating characteristic , predictive value , hepatitis c , immunoassay , antibody , virology , positive predicative value , nucleic acid test , polymerase chain reaction , gastroenterology , immunology , virus , biology , covid-19 , biochemistry , gene , disease , infectious disease (medical specialty)

In the diagnosis of hepatitis C virus (HCV) infection, the first step is screening for anti-HCV antibodies, and positive results are generally confirmed with nucleic acid amplification tests. Recent studies have reported that more compatible results have been obtained with the HCV RNA test using signal to cut-off (S/Co) values >1, which are the routine reactivity threshold for the anti-HCV enzyme immunoassay (EIA) test. The aim of this study was to determine the most appropriate S/Co value for the anti-HCV test, predicting HCV infection.

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