Effect of aminophylline on the pharmacokinetics of amikacin in Sprague-Dawley rats | Zendy

Seth Kwabena Amponsah | Zendy; Kwabena F.M. Opuni | Zendy; Kwabena Aboagye Antwi | Zendy; Victor Pouzuing Kunkpeh | Zendy

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Effect of aminophylline on the pharmacokinetics of amikacin in Sprague-Dawley rats

Author(s) -

Seth Kwabena Amponsah,

Kwabena F.M. Opuni,

Kwabena Aboagye Antwi,

Victor Pouzuing Kunkpeh

Publication year - 2019

Publication title -

the journal of infection in developing countries

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.322

H-Index - 49

eISSN - 2036-6590

pISSN - 1972-2680

DOI - 10.3855/jidc.10514

Subject(s) - aminophylline , pharmacokinetics , amikacin , medicine , pharmacology , anesthesia , antibiotics , biology , microbiology and biotechnology

In most resource-poor settings, amikacin is normally co-administered with aminophylline among preterm newborns with infection and apnea of prematurity. There is the likelihood of an interaction between concurrently administered amikacin that is excreted almost solely via kidneys, and aminophylline, which is known to increase filtration fraction. The aim of this study was to evaluate the effect of aminophylline on the pharmacokinetics of amikacin using an animal model.

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