Antiviral Activity of 1,4-Disubstituted-1,2,3-Triazoles against HSV-1 in vitro | Zendy

Daiane J. Viegas | Zendy; Verônica Diniz da Silva | Zendy; Camilla D. Buarque | Zendy; David C. Bloom | Zendy; Paula Alvarez Abreu | Zendy

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Antiviral Activity of 1,4-Disubstituted-1,2,3-Triazoles against HSV-1 in vitro

Author(s) -

Daiane J. Viegas,

Verônica Diniz da Silva,

Camilla D. Buarque,

David C. Bloom,

Paula Alvarez Abreu

Publication year - 2019

Publication title -

antiviral therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.747

H-Index - 87

eISSN - 2040-2058

pISSN - 1359-6535

DOI - 10.3851/imp3387

Subject(s) - herpes simplex virus , viral replication , cytotoxicity , population , virology , virus , ec50 , thymidine , in vitro , cytotoxic t cell , ic50 , thymidine kinase , biology , chemistry , medicine , biochemistry , environmental health

Herpes simplex virus 1 (HSV-1) affects a large part of the adult population. Anti-HSV-1 drugs, such as acyclovir, target thymidine kinase and viral DNA polymerase. However, the emerging of resistance of HSV-1 alerts for the urgency in developing new antivirals with other therapeutic targets. Thus, this study evaluated a series of 1,4-disubstituted-1,2,3-triazole derivatives against HSV-1 acute infection and provided deeper insights into the possible mechanisms of action.

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