Peripheral T-Cell Apoptosis is Not Differentially Affected by Antiretroviral Regimens in HIV-Infected Patients | Zendy

Thijs Feuth | Zendy; Debbie van Baarle | Zendy; Andy I. M. Hoepelman | Zendy; Joop E. Arends | Zendy

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Peripheral T-Cell Apoptosis is Not Differentially Affected by Antiretroviral Regimens in HIV-Infected Patients

Author(s) -

Thijs Feuth,

Debbie van Baarle,

Andy I. M. Hoepelman,

Joop E. Arends

Publication year - 2013

Publication title -

antiviral therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.747

H-Index - 87

eISSN - 2040-2058

pISSN - 1359-6535

DOI - 10.3851/imp2644

Subject(s) - peripheral , human immunodeficiency virus (hiv) , antiretroviral therapy , apoptosis , medicine , virology , viral load , didanosine , immunology , biology , genetics

HIV-induced CD4(+) and CD8(+) T-cell apoptosis decreases upon start of combination antiretroviral therapy (cART). Although in vitro evidence suggests an anti-apoptotic effect of protease inhibitors (PIs) as opposed to non-nucleoside reverse transcriptase inhibitors (NNRTIs), in vivo studies are inconclusive about effects of differential cART regimens on T-cell apoptosis.

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