Antiviral Agents Derived from Novel 1-adamantyl Singlet Nitrenes | Zendy

Andreas J. Kesel | Zendy; HansChristoph Weiß | Zendy; Andreas Schönleber | Zendy; Craig W. Day | Zendy; Dale L. Barnard | Zendy; Mervi Detorio | Zendy; Raymond F. Schinazi | Zendy

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Antiviral Agents Derived from Novel 1-adamantyl Singlet Nitrenes

Author(s) -

Andreas J. Kesel,

HansChristoph Weiß,

Andreas Schönleber,

Craig W. Day,

Dale L. Barnard,

Mervi Detorio,

Raymond F. Schinazi

Publication year - 2012

Publication title -

antiviral chemistry and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.919

H-Index - 51

eISSN - 2040-2066

pISSN - 0956-3202

DOI - 10.3851/imp2485

Subject(s) - amantadine , synthon , phenacyl , rimantadine , biology , virology , stereochemistry , influenza a virus , chemistry , virus , medicinal chemistry

Amantadine constitutes an interesting, diamond crystal lattice-shaped, antivirally active amine with an inhibitory effect on influenza A viruses causing common 'flu' in humans. Unfortunately, amantadine forfeited most of its therapeutic potential because of resistance development in recent influenza A virus isolates. The antiviral efficacy of amantadine congeners can be chemically modified, resulting in re-constitution, improvement and/or extension of antiviral activities mediated by amino-adamantyls.

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