Antiretroviral Monocyte Efficacy Score Linked to Cognitive Impairment in Hiv | Zendy

Cecilia M. Shikuma | Zendy; Beau K. Nakamoto | Zendy; Bruce Shiramizu | Zendy; Chin-Yuan Liang | Zendy; Victor DeGruttola | Zendy; Kara Bennett | Zendy; Robert Paul | Zendy; Kalpana J. Kallianpur | Zendy; Dominic C. Chow | Zendy; Christina Gavegnano | Zendy; Selwyn J. Hurwitz | Zendy; Raymond F. Schinazi | Zendy; Victor Valcour | Zendy

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Antiretroviral Monocyte Efficacy Score Linked to Cognitive Impairment in Hiv

Author(s) -

Cecilia M. Shikuma,

Beau K. Nakamoto,

Bruce Shiramizu,

Chin-Yuan Liang,

Victor DeGruttola,

Kara Bennett,

Robert Paul,

Kalpana J. Kallianpur,

Dominic C. Chow,

Christina Gavegnano,

Selwyn J. Hurwitz,

Raymond F. Schinazi,

Victor Valcour

Publication year - 2012

Publication title -

antiviral therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.747

H-Index - 87

eISSN - 2040-2058

pISSN - 1359-6535

DOI - 10.3851/imp2411

Subject(s) - neurocognitive , medicine , cohort , odds ratio , dementia , cohort study , cognition , psychiatry , disease

Monocytes transmigrating to the brain play a central role in HIV neuropathology. We hypothesized that the continued existence of neurocognitive impairment (NCI) despite potent antiretroviral (ARV) therapy is mediated by the inability of such therapy to control this monocyte/macrophage reservoir.

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