Effects of a Reduced Dose of Stavudine on the Incidence and Severity of Peripheral Neuropathy in HIV-Infected Adults in South Africa | Zendy

Meera Pahuja | Zendy; Anneke Grobler | Zendy; Marshall J. Glesby | Zendy; Farina Karim | Zendy; Gary E. Parker | Zendy; Sizwe Gumede | Zendy; Kogieleum Naidoo | Zendy

Open Access

Effects of a Reduced Dose of Stavudine on the Incidence and Severity of Peripheral Neuropathy in HIV-Infected Adults in South Africa

Author(s) -

Meera Pahuja,

Anneke Grobler,

Marshall J. Glesby,

Farina Karim,

Gary E. Parker,

Sizwe Gumede,

Kogieleum Naidoo

Publication year - 2012

Publication title -

antiviral therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.747

H-Index - 87

eISSN - 2040-2058

pISSN - 1359-6535

DOI - 10.3851/imp2087

Subject(s) - medicine , stavudine , peripheral neuropathy , incidence (geometry) , cohort , retrospective cohort study , guideline , population , cohort study , surgery , viral load , antiretroviral therapy , immunology , human immunodeficiency virus (hiv) , diabetes mellitus , pathology , physics , environmental health , optics , endocrinology

Although recent World Health Organization (WHO) guidelines recommend withdrawing stavudine (d4T) from first-line antiretroviral therapy (ART), it remains commonly used in resource-limited settings. In 2006, WHO recommended decreasing the dose of d4T from 40 mg to 30 mg to mitigate toxicities. We compared the incidence and severity of peripheral neuropathy by d4T dose in a retrospective cohort study.

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