Bioequivalence of Dispersed Stavudine: Opened versus Closed Capsule Dosing | Zendy

Steve Innes | Zendy; Jennifer Norman | Zendy; Pete Smith | Zendy; Marlize Smuts | Zendy; Edmund V. Capparelli | Zendy; Bernd Rosenkranz | Zendy; Mark F. Cotton | Zendy

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Bioequivalence of Dispersed Stavudine: Opened versus Closed Capsule Dosing

Author(s) -

Steve Innes,

Jennifer Norman,

Pete Smith,

Marlize Smuts,

Edmund V. Capparelli,

Bernd Rosenkranz,

Mark F. Cotton

Publication year - 2011

Publication title -

antiviral therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.747

H-Index - 87

eISSN - 2040-2058

pISSN - 1359-6535

DOI - 10.3851/imp1876

Subject(s) - stavudine , bioequivalence , capsule , dosing , pharmacokinetics , medicine , bioavailability , pharmacology , crossover study , reverse transcriptase inhibitor , human immunodeficiency virus (hiv) , zidovudine , biology , virology , antiretroviral therapy , viral load , pathology , viral disease , botany , alternative medicine , placebo

Stavudine, a nucleoside reverse transcriptase inhibitor, is used commonly to treat HIV-infected children in the developing world. The paediatric liquid formulation presents major logistical difficulties in rural and resource-limited areas, and prescribers are frequently forced to employ off-label 'opened capsule' dosing methods using the adult capsule. The South African Department of Health (DoH) has advised that caregivers should be instructed to disperse the contents of an adult capsule in 5 ml water and then withdraw the required dose using a syringe. The bioavailability of stavudine using the opened capsule dosing method has not previously been validated.

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