Mechanism of Interaction of Novel Indolylarylsulfone Derivatives with K103N and Y181I Mutant HIV-1 Reverse Transcriptase in Complex with its Substrates | Zendy

Alberta Samuele | Zendy; Sara Bisi | Zendy; Alexandra Kataropoulou | Zendy; Giuseppe La Regina | Zendy; Francesco Piscitelli | Zendy; Valerio Gatti | Zendy; Romano Silvestri | Zendy; Giovanni Maga | Zendy

Open Access

Mechanism of Interaction of Novel Indolylarylsulfone Derivatives with K103N and Y181I Mutant HIV-1 Reverse Transcriptase in Complex with its Substrates

Author(s) -

Alberta Samuele,

Sara Bisi,

Alexandra Kataropoulou,

Giuseppe La Regina,

Francesco Piscitelli,

Valerio Gatti,

Romano Silvestri,

Giovanni Maga

Publication year - 2011

Publication title -

antiviral chemistry and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.919

H-Index - 51

eISSN - 2040-2066

pISSN - 0956-3202

DOI - 10.3851/imp1855

Subject(s) - reverse transcriptase , mutant , nucleoside reverse transcriptase inhibitor , docking (animal) , chemistry , nucleotidyltransferase , enzyme , reverse transcriptase inhibitor , integrase , biology , rational design , stereochemistry , human immunodeficiency virus (hiv) , virology , biochemistry , genetics , rna , gene , medicine , nursing

Novel indolylarylsulfones (IASs), designed through rational structure-based molecular modelling and docking approaches, have been recently characterized as effective inhibitors of the wild-type and drug-resistant mutant HIV-1 reverse transcriptase (RT).

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