In Vitro and in Vivo Anti-Influenza Virus Activity of Diarylheptanoids Isolated from Alpinia Officinarum | Zendy

Rie Sawamura | Zendy; Tomomi Shimizu | Zendy; Yi Sun | Zendy; Ken Yasukawa | Zendy; Motofumi Miura | Zendy; Masaharu Toriyama | Zendy; Shigeyasu Motohashi | Zendy; Wataru Watanabe | Zendy; Katsuhiko Konno | Zendy; Masahiko Kurokawa | Zendy

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In Vitro and in Vivo Anti-Influenza Virus Activity of Diarylheptanoids Isolated from Alpinia Officinarum

Author(s) -

Rie Sawamura,

Tomomi Shimizu,

Yi Sun,

Ken Yasukawa,

Motofumi Miura,

Masaharu Toriyama,

Shigeyasu Motohashi,

Wataru Watanabe,

Katsuhiko Konno,

Masahiko Kurokawa

Publication year - 2010

Publication title -

antiviral chemistry and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.919

H-Index - 51

eISSN - 2040-2066

pISSN - 0956-3202

DOI - 10.3851/imp1676

Subject(s) - virus , in vivo , virology , biology , influenza a virus , oseltamivir , in vitro , orthomyxoviridae , mode of action , microbiology and biotechnology , medicine , biochemistry , disease , covid-19 , pathology , infectious disease (medical specialty)

Diarylheptanoids (AO-0002 [7-(4''-hydroxy-3''-methoxyphenyl)-1-phenyl-4E-hepten-3-one] and AO-0011 [(5S)-5-hydroxy-7-(4''-hydroxyphenyl)-1-phenyl-3-heptanone]) isolated from Alpinia officinarum have been reported to exhibit anti-influenza virus activity in vitro. Hence, efficacies against influenza virus infection and the mode of antiviral action were evaluated in vivo and in vitro, respectively.

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