Do activities of cytochrome P450 (CYP)3A, CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients? | Zendy

Alexander Jetter | Zendy; Gerd Fätkenheuer | Zendy; Dorothee Frank | Zendy; Tobias Klaassen | Zendy; Angela Seeringer | Zendy; Oxana Doroshyenko | Zendy; Julia Kirchheiner | Zendy; W Hein | Zendy; Edgar Schömig | Zendy; Uwe Fuhr | Zendy; Christoph Wyen | Zendy

Open Access

Do activities of cytochrome P450 (CYP)3A, CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients?

Author(s) -

Alexander Jetter,

Gerd Fätkenheuer,

Dorothee Frank,

Tobias Klaassen,

Angela Seeringer,

Oxana Doroshyenko,

Julia Kirchheiner,

W Hein,

Edgar Schömig,

Uwe Fuhr,

Christoph Wyen

Publication year - 2010

Publication title -

antiviral therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.747

H-Index - 87

eISSN - 2040-2058

pISSN - 1359-6535

DOI - 10.3851/imp1648

Subject(s) - cyp3a , dextromethorphan , dextrorphan , medicine , cyp2d6 , pharmacokinetics , pharmacology , efavirenz , area under the curve , p glycoprotein , cyp3a5 , cyp2c9 , cyp3a4 , confidence interval , digoxin , cytochrome p450 , gastroenterology , immunology , viral load , biology , human immunodeficiency virus (hiv) , drug resistance , genotype , antiretroviral therapy , biochemistry , microbiology and biotechnology , metabolism , multiple drug resistance , gene , heart failure

In inflammation and infection, cytochrome P450 (CYP) enzyme activities are down-regulated. Information on possible discrepancies in activities of CYP enzymes and drug transporters between HIV-infected patients and healthy people is limited.

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