The Design, Synthesis and Antiviral Evaluation of a Series of 5-trimethylsilyl-1-β-d-(arabinofuranosyl) uracil phosphoramidate ProTides | Zendy

Youcef Mehellou | Zendy; Jan Balzarini | Zendy; Christopher McGuigan | Zendy

Open Access

The Design, Synthesis and Antiviral Evaluation of a Series of 5-trimethylsilyl-1-β-d-(arabinofuranosyl) uracil phosphoramidate ProTides

Author(s) -

Youcef Mehellou,

Jan Balzarini,

Christopher McGuigan

Publication year - 2010

Publication title -

antiviral chemistry and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.919

H-Index - 51

eISSN - 2040-2066

pISSN - 0956-3202

DOI - 10.3851/imp1476

Subject(s) - phosphoramidate , uracil , nucleoside , uridine , nucleoside analogue , chemistry , biochemistry , herpes simplex virus , trimethylsilyl , virus , stereochemistry , biology , rna , virology , dna , organic chemistry , gene

Nucleoside analogues always require phosphorylation to be active. This appears to be a particular limitation for uridine-based nucleosides. Our ProTide method allows the direct use of masked membrane-soluble preformed nucleoside phosphates, bypassing the need for the initial phosphorylation step. We herein applied it to some novel 5-trimethylsilyl arabinosyl uridines.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research