Susceptibility to Genital Herpes as a Biomarker Predictive of Increased HIV Risk: Expansion of a Murine Model of Microbicide Safety | Zendy

Sarah S. Wilson | Zendy; Natalia Cheshenko | Zendy; Esra Fakioglu | Zendy; Pedro M. M. Mesquita | Zendy; Marla J. Keller | Zendy; Betsy C. Herold | Zendy

Open Access

Susceptibility to Genital Herpes as a Biomarker Predictive of Increased HIV Risk: Expansion of a Murine Model of Microbicide Safety

Author(s) -

Sarah S. Wilson,

Natalia Cheshenko,

Esra Fakioglu,

Pedro M. M. Mesquita,

Marla J. Keller,

Betsy C. Herold

Publication year - 2009

Publication title -

antiviral therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.747

H-Index - 87

eISSN - 2040-2058

pISSN - 1359-6535

DOI - 10.3851/imp1463

Subject(s) - microbicides for sexually transmitted diseases , microbicide , immunology , herpes simplex virus , epithelium , vaginal microbicide , medicine , virology , placebo , biology , virus , pathology , population , human immunodeficiency virus (hiv) , alternative medicine , environmental health , health services

A crucial gap in the development of microbicides for HIV prevention is the absence of models predictive of safety. Previous studies have demonstrated an increased susceptibility to genital herpes in mice following repeated applications of nonoxynol-9 (N-9). This study was designed to explore the underlying mechanisms, focusing on the effects that N-9 has on genital tract epithelium and to apply this expanded model to evaluate the safety of microbicides that have been advanced to clinical trials.

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