Open AccessThe Effect of a 4th Generation-Cephalosporin Introduction upon the Incidence of Multidrug-Resistant Gram-Negative Bacteria in a Non-Teaching Hospital
Author(s) -
Guilherme Henrique Campos Furtado,
Luciana Baria Perdiz,
Eduardo Alexandrino Medeiros
Publication year - 2008
Publication title -
american journal of infectious diseases
Language(s) - English
Resource type - Journals
eISSN - 1558-6340
pISSN - 1553-6203
DOI - 10.3844/ajidsp.2008.267.271
Subject(s) - cephalosporin , gram , gram negative bacteria , multiple drug resistance , incidence (geometry) , medicine , microbiology and biotechnology , bacteria , intensive care medicine , antibiotics , biology , mathematics , escherichia coli , biochemistry , genetics , gene , geometry
Problem statement: Antimicrobial resistance is a worrisome situation
in hospitals around the world and the misuse of certain classes of antimicrobials
has contributed for this situation. Approach: We performed a
prospective surveillance study on the incidence of multi-drug resistant bacteria
before (phase 1) and after (phase 2) the introduction of a 4th-generation cephalosporin
in a non-teaching hospital. Results: There was a significant
reduction in the incidence of Enterobacter species (from 1.3 isolates per 100
patient-days to 0.39 isolates per 100 patient-days, p = 0.01) between the two
periods. We also observed a reduction in the consumption of ceftazidime (from
64.3 DDD per 1000 patient-days to 29.6 DDD per 1000 patient-days, p = 0.002) and
ceftriaxone (from 323.9 DDD per 1000 patient-days to 246.2 DDD per 1000 patient-days,
p = 0.01). Conclusion: The introduction of a 4th-generation cephalosporin
in our setting resulted in an important reduction in the incidence of Enterobacter
species