Open AccessPathophysiology of Adipocyte Defects and Dyslipidemia in HIV Lipodystrophy: New Evidence from Metabolic and Molecular Studies
Author(s) -
Ashok Balasubramanyam,
Rajagopal V. Sekhar,
Farook Jahoor,
Henry J. Pownall,
Dorothy E. Lewis
Publication year - 2006
Publication title -
american journal of infectious diseases
Language(s) - English
Resource type - Journals
eISSN - 1558-6340
pISSN - 1553-6203
DOI - 10.3844/ajidsp.2006.167.172
Subject(s) - dyslipidemia , lipodystrophy , pathophysiology , adipocyte , medicine , human immunodeficiency virus (hiv) , physiology , bioinformatics , endocrinology , biology , adipose tissue , diabetes mellitus , antiretroviral therapy , immunology , viral load
Despite a burgeoning mass of descriptive information regarding the epidemiology, clinical features, body composition changes, hormonal alterations and dyslipidemic patterns in patients with HIV lipodystrophy syndrome (HLS), the specific biochemical pathways that are dysregulated in the condition and the molecular mechanisms that lead to their dysfunction, remain relatively unexplored. In this paper, we review studies that detail the metabolic basis of the dyslipidemia - specifically, the hypertriglyceridemia - that is the serologic hallmark of HLS and present new data relevant to mechanisms of dyslipidemia in the postprandial state. We also describe preliminary experiments showing that in addition to the well-known effects of highly-active antiretroviral drugs, the functional disruption of adipocytes and preadipocytes by factors intrinsic to HIV-infected immunocytes may play a role in the pathogenesis of HLS