Open AccessEffects of Salmonella typhimurium Challenge on Swine Growth, Nitrogen Balance, Insulin-like Growth Factor-I, and Acute Phase Proteins
Author(s) -
J.A. Loughmiller,
S. S. Dritz,
Jim L. Nelssen,
Tokach,
Robert D. Goodband,
Stephen A. Moser,
M. De La Llata
Publication year - 2007
Publication title -
american journal of animal and veterinary sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.174
H-Index - 15
eISSN - 1557-4563
pISSN - 1557-4555
DOI - 10.3844/ajavsp.2007.11.22
Subject(s) - salmonella , insulin like growth factor , nitrogen balance , growth factor , phase (matter) , acute phase protein , nitrogen , insulin , food science , biology , bacterial growth , zoology , microbiology and biotechnology , chemistry , biochemistry , bacteria , immunology , inflammation , genetics , receptor , organic chemistry
Growing barrows were used to determine the effects of an en teric disease challenge on nutrient balance, growth, acute phase proteins, and IGF-I. Pigs were challenged on d 0 with Salmonella typhimurium (S; N=21), or unchallenged and fed ad libitum (A; n=6), or unchallenged and pair-fed the same amount of feed as a challenged pig (P; n=8). Blood was collected on d -3, 1, 5, 9, and 15. A disease challenge ï´ time interaction was observed for serum haptoglobin (P < 0.05), with greater haptoglobin for S vs A on d 1 and 5 (P < 0.05) and for S vs P on d 5 (P < 0.05). Plasma IGF-I increased from d -3 to 17 (linear, P < 0.05) and was increased for S vs A on d 9 (P < 0.06) and d 15 (P < 0.03), and for S vs P (P < 0.02) on d 9. A disease challenge ï´ time interaction was observed (P < 0.05) for average daily gain as it decreased for S (.62 kg) vs A (1.38 kg; P < 0.01) and P (.95 kg; P < 0.07) from d 0 to 3. A disease challenge× time interaction was observed for retained nitrogen (N; P < 0.05), indicating reduced lean growth from d 0 to 3 for S (19.6 g/d; P < 0.01) and P (23.2 g/d; P < 0.07) vs A (30.1 g/d). Although short-term differences were evident, d 0 to 17 growth performance and N balance were not affected by an acute S. typhimurium challenge (P > 0.20). Results indicate that 66% of the short-term reductions in average daily gain from an acute S. typhimurium disease challenge are due to reductions in feed intake. The remaining differences are due to the acute phase immune response