Protective effect of Thymus quinquecostatus extracts UVB-induced matrix metalloproteinase-1 via suppressing MAPKs phosphorylation in human keratinocyte | Zendy

Hana Jung | Zendy; Hyun Ju Jeong | Zendy; Kyoung-Hee Shin | Zendy; Yung Sun Kim | Zendy; Jae Heon Moon | Zendy; Tae Hoon Lee | Zendy

Open Access

Protective effect of Thymus quinquecostatus extracts UVB-induced matrix metalloproteinase-1 via suppressing MAPKs phosphorylation in human keratinocyte

Author(s) -

Hana Jung,

Hyun Ju Jeong,

Kyoung-Hee Shin,

Yung Sun Kim,

Jae Heon Moon,

Tae Hoon Lee

Publication year - 2018

Publication title -

journal of applied biological chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.229

H-Index - 18

eISSN - 2234-7941

pISSN - 1976-0442

DOI - 10.3839/jabc.2018.059

Subject(s) - matrix metalloproteinase , chemistry , phosphorylation , p38 mitogen activated protein kinases , human skin , ultraviolet , kinase , stimulation , microbiology and biotechnology , signal transduction , keratinocyte , protein kinase a , biochemistry , in vitro , endocrinology , biology , optoelectronics , materials science , genetics

Ultraviolet rays are electromagnetic waves with a shorter wavelength than visible light, and ultraviolet rays that pass through the ozone layer are the main cause of skin aging. Chronic exposure of skin tissue to ultraviolet light activates the Mitogenactivated Protein Kinases (MAPKs) signaling pathways in human keratinocytes, resulting in increased production of matrix metalloproteinases (MMPs). In this study, we investigated the herbal extracts from Jeju Island on the anti-aging effect in human keratinocytes (HaCaTs) by ultraviolet stimulation. We examined that herb extract from Jeju Island were decreased in anti-aging activity on measuring the level of MMP-1 gene and protein expression in ultraviolet-induced keratinocytes. As a result, it was confirmed that Thymus quinquecostatus extract (TQE) significantly reduced the expression of MMP-1 in a dose-dependent manner by UV irradiated HaCaTs. According to our data, TQE significantly attenuated UV-induced phosphorylation of the MAPKs signaling elements ERK1/2, JNK1/2 and p38 proteins. These results suggest that the MAPKs pathway may contribute to the inhibitory effect of TQE on UV-induced MMP-1 production in human keratinocytes. Our results suggest that TQE may be a protective agent against skin aging by preventing UV-induced MMP-1 production.

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