Whitening Effects of Solvent Fractions Isolated from Vitex rotundifolia | Zendy

Jae-Myo Yu | Zendy; Dong Hee Kim | Zendy; JunHo Son | Zendy

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Whitening Effects of Solvent Fractions Isolated from Vitex rotundifolia

Author(s) -

Jae-Myo Yu,

Dong Hee Kim,

JunHo Son

Publication year - 2015

Publication title -

journal of applied biological chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.229

H-Index - 18

eISSN - 2234-7941

pISSN - 1976-0442

DOI - 10.3839/jabc.2015.042

Subject(s) - chemistry , depigmentation , vitex , tyrosinase , melanin , microphthalmia associated transcription factor , traditional medicine , botany , biochemistry , dermatology , enzyme , biology , medicine

Recently many effort focused to understand the mechanical insights of melanogenesis to develop the agent for hyper-pigmentation. So this study was performed to investigate the depigmentation of Vitex rotundifolia. With B16F10 mouse melanoma cell, we have seen inhibition of the tyrosinase, MITF, TRP-1, TRP-2, and melanin synthesis, which eventually were dose dependently decreased by Vitex rotundifolia. Specially, Vitex rotundifolia decreased the protein levels of tyrosinase and TRP-1. In conclusion, Vitex rotundifolia showed the whitening activity in all the experiments mentioned above and we expect that it can be used for preventing melanin synthesis.

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