Epigenetic silencing during early lineage commitment | Zendy

Howard Cedar | Zendy; Yehudit Bergman | Zendy

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Epigenetic silencing during early lineage commitment

Author(s) -

Howard Cedar,

Yehudit Bergman

Publication year - 2009

Publication title -

stembook

Language(s) - English

Resource type - Journals

ISSN - 1940-3429

DOI - 10.3824/stembook.1.42.1

Subject(s) - reprogramming , dna methylation , epigenetics , chromatin , biology , gene silencing , somatic cell , lineage (genetic) , genetics , methylation , microbiology and biotechnology , gene , gene expression

A large part of the genome is repressed in animal cells. This expression profile is set up during early developmentthroughanumberofdifferentmechanisms,includingsite-specificrepressioncomplexesandglobal DNA methylation which probably work by generating inaccessible chromatin structures. This overall pattern is thenlargelymaintainedthroughoutdevelopment.Earlylineagecommitmentisassociatedwiththeturningoffof pluripotency genes through programmed heterochromatinization, with DNA methylation providing long-term stability and inhibiting somatic cell reprogramming.

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