Epidemiology and Antibiotic Susceptibility Patterns of Carbapenem Resistant Gram Negative Bacteria Isolated from Two Tertiary Care Hospitals in North Lebanon | Zendy

Monzer Hamzé | Zendy

Open Access

Epidemiology and Antibiotic Susceptibility Patterns of Carbapenem Resistant Gram Negative Bacteria Isolated from Two Tertiary Care Hospitals in North Lebanon

Author(s) -

Monzer Hamzé

Publication year - 2018

Publication title -

the international arabic journal of antimicrobial agents

Language(s) - English

Resource type - Journals

ISSN - 2174-9094

DOI - 10.3823/823

Subject(s) - tigecycline , colistin , acinetobacter baumannii , carbapenem , amikacin , enterobacter , microbiology and biotechnology , antibiotic resistance , antibiotics , fosfomycin , antimicrobial , medicine , acinetobacter , gram negative bacteria , biology , pseudomonas aeruginosa , bacteria , escherichia coli , biochemistry , genetics , gene

Background: Antimicrobial resistance is a major public health problem worldwide. Numerous epidemiological studies reported that Lebanon is affected with high levels of antibiotic resistance. The aim of this study is to determine the prevalence and antibiotic susceptibility patterns of carbapenem-resistant Gram-negative bacteria in North Lebanon during the period 2015-2017. Methods: Carbapenem-resistant Gram-negative bacteria were isolated from patients referring to Nini hospital and Youssef hospital center. Identification and antibiotic susceptibility testing were performed through conventional tools according to the manufacturer’s recommended procedures and the recommendations of the European Committee on Antimicrobial Susceptibility Testing, respectively. Results: Overall, a total of 290 carbapenem-resistant Gram-negative bacteria were isolated. Escherichia coli was predominant and represented 39.3% of all isolates, followed by Pseudomonas aeruginosa (24.8%), Acinetobacter baumannii (22.8%), Klebsiella spp. (8.6%), Enterobacter spp. (6.6%), Pantoea spp. (1%), and Proteus vulgaris (0.3%). Our findings showed an alarming increase in the prevalence of carbapenem resistant bacteria during the investigation period. On the other hand, colistin, tigecycline, amikacin and fosfomycin remain the most effective agents against carbapenem-resistant Gram-negative bacteria. Epidemiology and antibiotic susceptibility patterns of carbapenem-resistant Gram-negative bacteria isolated from two tertiary care hospitals in North Lebanon Monzer Hamze1, Marwan Osman1,3, Hassan Mallat1,2,3, Sandy Nasr1, Elie Bou Raad3, Marcel Achkar2 1 Laboratoire Microbiologie Santé et Environnement (LMSE), Doctoral School of Sciences and Technology, Faculty of Public Health, Lebanese University, Tripoli, Lebanon. 2 Clinical Laboratory, Nini Hospital, Tripoli, Lebanon. 3 Youssef Hospital Center, Akkar, Lebanon. Contact information:

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