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Object: This study aimed to investigate the effects of Passiflora incarnata L. on anxiety in humans.\udMethod: The individuals were randomly assigned to one of the following groups: Placebo or experimental, n =30, single dose, as well as Placebo or Experimental, n =15, multiple dose.  The experimental human anxiety was induced by simulated public speaking test in the following phases: Basal (B), stressful (A), speech 1 (S1), speech 2 (S2) and Final (F). We evaluated the Systolic Blood Pressure (SBP), and Diastolic (DBP), Heart Rate (HR), Electrical Conductance of Skin and extremities temperature (ET) and filled The state-trait anxiety inventory (STAI S e T).\udResults: During the single dose, the HR was reduced at the end of the speech (86±2,0 to 74±3,0 bpm) the experimental group compared to the placebo group (p<0,05); the STAI-S did not change. In the delineation of multiple doses, SBP was reduced, in mmHg, in the experimental group compared to the placebo group during all phases. Experimental: 106±1,0 (B), 111±1,0 (A), 121±2,0 (S1), 115±3 (S2), 104±2,0 (F) e Placebo: 121±3,0; 127±3,0; 130±3,0; 130±4,5; 117±3,0 (p<0,05).\udConclusions: It is suggested that supplementation using Passiflora incarnata L. Capsules (500 mg) decreased cardiovascular signals both in single and in multiple doses, associated with the stress of public speaking

international archives of medicine

Effects of the single supplementation and multiple doses of Passiflora incarnata L. on human anxiety: A Clinical Trial, Double-blind, Placebo-controlled, Randomized