Inhibition of drug-sensitive and drug-resistant Mycobacterium tuberculosis strains by essential oil from Croton argyrophylloides Mull. Arg. | Zendy

José Antônio Barreto Alves | Zendy; Mariângela da Silva Nunes | Zendy; Ricardo Fakhouri | Zendy; Paulo Ricardo MartinsFilho | Zendy; María do Carmo de Oliveira Ribeiro | Zendy; Alberto Correa de Vasconcellos | Zendy; Patrícia Oliveira Santos | Zendy; Murilo Marchioro | Zendy; Rita de Cássia Trindade | Zendy; Gladslene Góes Santos Frazão | Zendy; Andréia Centenaro Vaez | Zendy; Karine Vaccaro Tako | Zendy

Open Access

Inhibition of drug-sensitive and drug-resistant Mycobacterium tuberculosis strains by essential oil from Croton argyrophylloides Mull. Arg.

Author(s) -

José Antônio Barreto Alves,

Mariângela da Silva Nunes,

Ricardo Fakhouri,

Paulo Ricardo MartinsFilho,

María do Carmo de Oliveira Ribeiro,

Alberto Correa de Vasconcellos,

Patrícia Oliveira Santos,

Murilo Marchioro,

Rita de Cássia Trindade,

Gladslene Góes Santos Frazão,

Andréia Centenaro Vaez,

Karine Vaccaro Tako

Publication year - 2016

Publication title -

international archives of medicine

Language(s) - English

Resource type - Journals

ISSN - 1755-7682

DOI - 10.3823/2047

Subject(s) - antimycobacterial , ethambutol , croton , mycobacterium tuberculosis , medicine , streptomycin , isoniazid , rifampicin , essential oil , traditional medicine , tuberculosis , microbiology and biotechnology , drug resistance , drug , antibiotics , pharmacology , biology , food science , pathology

Objetcitve: To assess in vitro effects of essential oil extracted from Croton argyrophylloides against clinical and standard strains of Mycobacterium tuberculosis , comparing its resistance and sensitivity profiles to drugs commonly used in therapy. Method: In the present study, chemical composition and antimycobacterial activity of essential oils extracted from aerial parts of Croton argyrophylloides collected in Curituba district, Sergipe, Brazil were analysed. The oil was studied by GC and GC-MS and its antimicobacterial activity (MIC) was tested against 49 clinical and standard covers H 37 RV using the REMA method. To access sensitivity to isoniazid, rifampicin, ethambutol and streptomycin it was used proportions indirect test method. Results: Twenty-seven chemicals were identified, totalizing 95.98% of the composition of essential oil. The oil presented good antibacterial activity (MIC = 97 to 195 g / ml) against strains of Mycobacterium tuberculosis H37Rv and pattern one. Conclusion: On pharmacological activities of these species confirmed in vitro scientific support for its use in traditional herbal preparations.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research