Successful thrombolysis of a thrombosed mechanical aortic valve prosthesis using a slow intravenous Tenecteplase infusion

Prosthetic valve thrombosis is defined as any obstruction of prosthesis by non-infective thrombotic material. It has an estimated incidence of 0.03%-4.3% per year and is reported to occur in 0.5%-8% of the left-sided prosthetic valves and in up to 20% of tricuspid prosthesis. We describe a successful treatment of a young man presented with a thrombosed prosthetic aortic valve using a slow intravenous infusion of Tenecteplase without any bolus dose in a newly described dose regimen for aortic valve position and with a complete resolution of the thrombus and regaining the full mobility of both valve leaflets within 48 hours.