Ultrastructural aspects of cranial and peripheric nerves of cronically diabetic and malnourished rats: a short biochemical panorama | Zendy

Ageu de Oliveira Saraiva | Zendy; Larissa Queiroz Pontes | Zendy; Lia Gonçalves Pinho | Zendy; Marcus Rafael Lobo Bezerra | Zendy; Hiroê Alencar Braga | Zendy; Nádia Nara Rolim Lima | Zendy; Carlos Augusto Carvalho de Vasconcelos | Zendy; Modesto Leite Rolim Neto | Zendy; Josè Luiz de Lima Filho | Zendy; Fábio André Brayner dos Santos | Zendy; Luiz Carlos Alves | Zendy; Marcelo Moraes Valênça | Zendy

Open Access

Ultrastructural aspects of cranial and peripheric nerves of cronically diabetic and malnourished rats: a short biochemical panorama

Author(s) -

Ageu de Oliveira Saraiva,

Larissa Queiroz Pontes,

Lia Gonçalves Pinho,

Marcus Rafael Lobo Bezerra,

Hiroê Alencar Braga,

Nádia Nara Rolim Lima,

Carlos Augusto Carvalho de Vasconcelos,

Modesto Leite Rolim Neto,

Josè Luiz de Lima Filho,

Fábio André Brayner dos Santos,

Luiz Carlos Alves,

Marcelo Moraes Valênça

Publication year - 2015

Publication title -

international archives of medicine

Language(s) - English

Resource type - Journals

ISSN - 1755-7682

DOI - 10.3823/1668

Subject(s) - medicine , diabetes mellitus , sirtuin , nad+ kinase , diabetic neuropathy , endocrinology , physiology , bioinformatics , enzyme , biology , biochemistry

Diabetes Mellitus is one of the most common causes of neuropathies, which can be caused by molecular imbalances that impair metabolic pathways. Studies in rats showed the importance of sirtuins (SIRT), deacetylases that use NAD+ as a cofactor, which have a widespread function in metabolism, and their relation when food deprived or calorie restricted. Additionally, diabetic neuropathy presents different structural biomarkers that cause morphological alterations in fibers that can be partially treated. SIRT1 is the principal sirtuin, which acts on hypothalamus, liver, kidney, among other organs, up regulating or down regulating the expression of some genes or enzymes crucial in the process of glucose absorption.

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