Extranodal NK/T-Cell Lymphoma without Nasal Cavity Involvement Associated with Epstein-Barr Virus: A Multimodality-Based Diagnosis of Two Cases | Zendy

Fernando Cobo | Zendy; Clara Ibel Chamorro | Zendy; Francisco Lúzio de Paula Ramos | Zendy; Ángel Concha | Zendy

Open Access

Extranodal NK/T-Cell Lymphoma without Nasal Cavity Involvement Associated with Epstein-Barr Virus: A Multimodality-Based Diagnosis of Two Cases

Author(s) -

Fernando Cobo,

Clara Ibel Chamorro,

Francisco Lúzio de Paula Ramos,

Ángel Concha

Publication year - 2009

Publication title -

scholarly research exchange

Language(s) - English

Resource type - Journals

eISSN - 1687-8302

pISSN - 1687-8299

DOI - 10.3814/2009/963781

Subject(s) - medicine , lymphoma , nasal cavity , pathology , chop , immunophenotyping , t cell lymphoma , granzyme b , t cell , immunology , antigen , immune system , surgery

We report two cases of extranodal NK/T-cell lymphoma, nasal type, in immunocompetent patients without nasal cavity involvement. In the two cases, the initial presumptive diagnosis was tuberculosis and there was a rapid dissemination of the tumor with short survival after the hospital admittance. An autopsy was performed showing infiltration in several organs including lymph nodes and mesenteric and retroperitoneal fat. Histological sections showed an angiocentric and angiodestructive growth pattern and the immunophenotype was CD45

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