Searching Genes Encoding Leishmania Antigens for Diagnosis and Protection | Zendy

Manuel Soto | Zendy; Laura Ramírez | Zendy; Miguel A. Pineda | Zendy; Vı́ctor M. González | Zendy; Petter F. Entringer | Zendy; Camila I. de Oliveira | Zendy; Ivan P. Nascimento | Zendy; Ana Paula Duarte de Souza | Zendy; Laura Corvo | Zendy; Carlos AlonsoMoreno | Zendy; Pedro Bonay | Zendy; Claudia Brodskyn | Zendy; Aldina Barral | Zendy; Manoel BarralNetto | Zendy; Salvador Iborra | Zendy

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Searching Genes Encoding Leishmania Antigens for Diagnosis and Protection

Author(s) -

Manuel Soto,

Laura Ramírez,

Miguel A. Pineda,

Vı́ctor M. González,

Petter F. Entringer,

Camila I. de Oliveira,

Ivan P. Nascimento,

Ana Paula Duarte de Souza,

Laura Corvo,

Carlos AlonsoMoreno,

Pedro Bonay,

Claudia Brodskyn,

Aldina Barral,

Manoel BarralNetto,

Salvador Iborra

Publication year - 2009

Publication title -

scholarly research exchange

Language(s) - English

Resource type - Journals

eISSN - 1687-8302

pISSN - 1687-8299

DOI - 10.3814/2009/173039

Subject(s) - leishmania , gene , antigen , leishmaniasis , leishmania major , isolation (microbiology) , virology , immunology , biology , medicine , computational biology , parasite hosting , genetics , bioinformatics , computer science , world wide web

Leishmaniases are a wide spectrum of parasitic diseases caused by the infection of different species of the genus Leishmania. Currently, these diseases are one of the most neglected diseases threatening 350 million people in different countries around the world. Thus, these diseases require better screening, diagnostics and treatment. An effective vaccine, that is not currently available, would be the best way to confront leishmaniases. In the past 20 years the molecular characterization of Leishmania genes encoding parasite antigens has been carried out. In this review we summarize the most common strategies employed for the isolation and characterization of genes encoding Leishmania antigens. To provide a collective view, we also discuss the results related with diagnosis and protection based on different recombinant DNA-derived Leishmania products.

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