New Approach for the Synthesis of Pyrido[1,2-a]pyrimidines | Zendy

Raghunath B. Toche | Zendy; Bhausaheb K. Ghotekar | Zendy; Muddassar A. Kazi | Zendy; Shivaraj P. Patil | Zendy; Madhukar N. Jachak | Zendy

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New Approach for the Synthesis of Pyrido[1,2-a]pyrimidines

Author(s) -

Raghunath B. Toche,

Bhausaheb K. Ghotekar,

Muddassar A. Kazi,

Shivaraj P. Patil,

Madhukar N. Jachak

Publication year - 2008

Publication title -

scholarly research exchange

Language(s) - English

Resource type - Journals

eISSN - 1687-8302

pISSN - 1687-8299

DOI - 10.3814/2008/434329

Subject(s) - sodium ethoxide , yield (engineering) , chemistry , ethanol , condensation , phosphorus , sodium , organic chemistry , medicinal chemistry , combinatorial chemistry , materials science , physics , metallurgy , thermodynamics

A novel method was successfully demonstrated towards the synthesis of pyrido[1,2-a]pyrimidines having chloroethyl as an intractable side chain, through dihydrofuranone intermediates. The dihydrofuranone intermediates were synthesized by condensation of 2-aminopyridines with α -acetyl- γ -butyrolactone, which upon cyclization using phosphorus oxychloride or ethanol in sodium ethoxide furnished the pyrido[1,2-a]pyrimidines in good yield.

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