E2/E6 ratio and L1 immunoreactivity as biomarkers to determine HPV16-positive high-grade squamous intraepithelial lesions (CIN2 and 3) and cervical squamous cell carcinoma | Zendy

Youn Jin Choi | Zendy; Ahwon Lee | Zendy; Tae Jung Kim | Zendy; Hyun-Tak Jin | Zendy; Yong-Bok Seo | Zendy; Jong Sup Park | Zendy; Sung Jong Lee | Zendy

Open Access

E2/E6 ratio and L1 immunoreactivity as biomarkers to determine HPV16-positive high-grade squamous intraepithelial lesions (CIN2 and 3) and cervical squamous cell carcinoma

Author(s) -

Youn Jin Choi,

Ahwon Lee,

Tae Jung Kim,

Hyun-Tak Jin,

Yong-Bok Seo,

Jong Sup Park,

Sung Jong Lee

Publication year - 2018

Publication title -

journal of gynecologic oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.358

H-Index - 37

eISSN - 2005-0399

pISSN - 2005-0380

DOI - 10.3802/jgo.2018.29.e38

Subject(s) - medicine , cervical intraepithelial neoplasia , basal cell , oncology , koilocyte , pathology , cancer research , cervical cancer , cancer

To our knowledge, this is the first study to validate HPV L1 capsid protein expression and decreased HPV E2/E6 ratio as valuable predictive markers of ≥CIN2 cervical lesions. Cervical cytology may be analyzed longitudinally on an outpatient basis with noninvasive procedures as against invasive conventional histologic analysis.

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