Open AccessGermline and somatic mutations in homologous recombination genes among Chinese ovarian cancer patients detected using next-generation sequencing
Author(s) -
Qianying Zhao,
Jiaxin Yang,
Lei Li,
Dongyan Cao,
Mei Yu,
Keng Shen
Publication year - 2017
Publication title -
journal of gynecologic oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.358
H-Index - 37
eISSN - 2005-0399
pISSN - 2005-0380
DOI - 10.3802/jgo.2017.28.e39
Subject(s) - medicine , germline , homologous recombination , somatic cell , germline mutation , ovarian cancer , gene , dna sequencing , genetics , homologous chromosome , mutation , cancer research , cancer , biology
our results suggest that a more comprehensive profiling of HR defect than merely BRCA1/2 could help elucidate tumor heterogeneity and lead to better stratification of ovarian cancer patients for individualized clinical management.
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