Hysteroscopy in fertility-sparing management for early endometrial cancer: a double-edged sword

The fertility-sparing management using progestin is now widely accepted as the alternative treatment for young women who eagerly want to preserve their fertility [1]. The selection of patients who will achieve complete response is the most important step for successful fertility-sparing management [1]. Patients with endometrium-confined, well-differentiated, endometrioid adenocarcinoma are the proper candidates for this treatment [1]. The pooled complete response rate is 76.2% (95% confidence interval [CI], 68.0%–85.3%) and recurrence rate among complete responder is 40.6% (95% CI, 33.1%–49.8%) in a recent meta-analysis [2]. The complete response rate is high, although the recurrence rate is high as well after achieving complete response. Therefore, the goal of this treatment is to delay definitive treatment until the completion of family planning. The most popular type of fertility-sparing management is to receive high-dose, continuous, daily oral progestin after removing endometrial cancer tissues by dilatation, curettage and biopsy (DCBx) as much as possible [1]. The use of hysteroscopic resection of endometrial cancer tissues may have merits and demerits compared to DCBx. Hysteroscopic examination of the endometrial cavity may increase the diagnostic accuracy by providing the direct estimation of the tumor extent and by providing information on the myometrial invasion [3]. Hysteroscopic resection of endometrial cancer tissues may increase the therapeutic efficacy by excising the tumor completely under direct vision. However, it may be harmful because the possibility of the spread of exfoliated endometrial cancer cells into peritoneal cavity by liquid expansion medium [4]. It may also impact adversely on the pregnancy outcome because it can cause injury to the basal layer of endometrium or underlying myometrium by thermal injury or mechanical destruction [5]. These possible positive and negative effects of hysteroscopy in the fertility-sparing management of endometrial cancer have never been evaluated in prospective trial. The questions are not solved yet and still debated.