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The current study included analysis the brain tissue structure after exposure to experimentally infection with Candida glabrata in BALB male mice which isolated from patients attending Tikrit Teaching Hospital suffering from Candimia (38 male, 25 female) aged (82-15 years). The results indicated different histopathological changes in the brains immunosuppressed studied mice, the results represented congestion of blood vessels of the five cerebral cortex layers, as well as the foamy appearance of the matrix of molecular layer of the cerebral cortex. In contrast the non-immunosuppressed mice group included histological changes represented with rupture of the pia matter, as well as shrinking or shrinkage of the six-layer cells of the adjoining cortex of the pia matter and the emergence of vacuoles around cells and nerve fibers on a large scale. The group of mice immunosuppressed show pathological changes represented with atrophy of pyramidal cells and glial cells in all layers of the cerebral cortex, as well as the spongylike appearance of the brain medulla, compared with the control group.

Histological structure in immune suppression male micebrain and other natural experimentally infected with Candida glabrata