Effect of probiotic Saccharomyces boulardii in weight losing and cytokines levels in mice before and after Infection by Salmonella typhimurium

This study was designed to evaluate some immunological and nutritional effects of three types of Sacchromyces boulardii yeasts, which was, Mutant Iraqi Isolate (Mutant Saccharomyces boulardii) MSb, commercial strain (Commercial Saccharomyces boulardii) CSb and Local Iraqi Isolate (Local Saccharomyces boulardii) LSb, in the weight and the level of both interleukin-10 (IL-10), interferon-gamma (IFN-γ) in the mice orally administered with yeasts inoculum for 30 days before and after infected with Salmonella typhimurium. The results shown significant losing in the weights and significant increase in the level of IL-10, but there are no significant difference in the levels of IFN-γ at )P>0.05) in mice administered with MSb, CSb and LSb yeasts before infected with S. typhimurium. The results also shown significant difference in the weights, significant increase in the level of IL-10 and significant decrease in the level of IFN-γ at )P>0.05) in mice administered with MSb, CSb and LSb yeasts after infected with S. typhimurium. Despite the effectiveness of three species of yeasts in these parameters before and after infection, but MSb was the most efficiency.