A 3D Spheroid Model for Glioblastoma | Zendy

Joris Guyon | Zendy; Laëtitia Andrique | Zendy; Nadège Pujol | Zendy; Gro Vatne Røsland | Zendy; Gaëlle Recher | Zendy; Andréas Bikfalvi | Zendy; Thomas Daubon | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A 3D Spheroid Model for Glioblastoma

Author(s) -

Joris Guyon,

Laëtitia Andrique,

Nadège Pujol,

Gro Vatne Røsland,

Gaëlle Recher,

Andréas Bikfalvi,

Thomas Daubon

Publication year - 2020

Publication title -

journal of visualized experiments

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.596

H-Index - 91

ISSN - 1940-087X

DOI - 10.3791/60998

Subject(s) - spheroid , glioblastoma , brain tumor , in vivo , neuroscience , biology , cell culture , pathology , computer science , computational biology , cancer research , medicine , genetics

Two-dimensional (2D) cell cultures do not mimic in vivo tumor growth satisfactorily. Therefore, three-dimensional (3D) culture spheroid models were developed. These models may be particularly important in the field of neuro-oncology. Indeed, brain tumors have the tendency to invade the healthy brain environment. We describe herein an ideal 3D glioblastoma spheroid-based assay that we developed to study tumor invasion. We provide all technical details and analytical tools to successfully perform this assay.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research