A Screenable In Vivo Assay for Mitochondrial Modulators Using Transgenic Bioluminescent Caenorhabditis elegans | Zendy

Cristina Lagido | Zendy; Debbie McLaggan | Zendy; L. Anne Glover | Zendy

Open Access

A Screenable <em>In Vivo</em> Assay for Mitochondrial Modulators Using Transgenic Bioluminescent <em>Caenorhabditis elegans</em>

Author(s) -

Cristina Lagido,

Debbie McLaggan,

L. Anne Glover

Publication year - 2015

Publication title -

journal of visualized experiments

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.596

H-Index - 91

ISSN - 1940-087X

DOI - 10.3791/53083

Subject(s) - caenorhabditis elegans , bioluminescence , transgene , microbiology and biotechnology , genetically modified mouse , biology , in vivo , mitochondrion , chemistry , genetics , biochemistry , gene

Acknowledgements The authors would like to thank David Gray from the Dundee Drug discovery unit for kindly donating firefly luciferase inhibitory compounds DDD00001434, DDD0001477, DDD635 and DDD00023047; Tibor Harkani (Medical University of Vienna) for the suggestion of oxaloacetate as a test compound; and Charlie Dear (University of Aberdeen) for illustrations. This work was funded by a BBSRC Pathfinder award (BB/FOF/PF/4/11) and the University of Aberdeen.Peer reviewedPublisher PD

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