Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products | Zendy

Chris Johnston | Zendy; E. Graeme Robertson | Zendy; Yvonne Harcus | Zendy; John R. Grainger | Zendy; Gillian Coakley | Zendy; Danielle J. Smyth | Zendy; Henry J. McSorley | Zendy; Rick M. Maizels | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Cultivation of <em>Heligmosomoides Polygyrus:</em> An Immunomodulatory Nematode Parasite and its Secreted Products

Author(s) -

Chris Johnston,

E. Graeme Robertson,

Yvonne Harcus,

John R. Grainger,

Gillian Coakley,

Danielle J. Smyth,

Henry J. McSorley,

Rick M. Maizels

Publication year - 2015

Publication title -

journal of visualized experiments

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.596

H-Index - 91

ISSN - 1940-087X

DOI - 10.3791/52412

Subject(s) - heligmosomoides polygyrus , biology , immunology , helminths , immune system , nematode , parasite hosting , microbiology and biotechnology , ecology , world wide web , computer science

Heligmosomoides polygyrus (formerly known as Nematospiroides dubius, and also referred to by some as H. bakeri ) is a gastrointestinal helminth that employs multiple immunomodulatory mechanisms to establish chronic infection in mice and closely resembles prevalent human helminth infections. H. polygyrus has been studied extensively in the field of helminth-derived immune regulation and has been found to potently suppress experimental models of allergy and autoimmunity (both with active infection and isolated secreted products). The protocol described in this paper outlines management of the H. polygyrus life cycle for consistent production of L3 larvae, recovery of adult parasites, and collection of their excretory-secretory products (HES).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research