Building a Better Mosquito: Identifying the Genes Enabling Malaria and Dengue Fever Resistance in A. gambiae and A. aegypti Mosquitoes | Zendy

George Dimopoulos | Zendy

Open Access

Building a Better Mosquito: Identifying the Genes Enabling Malaria and Dengue Fever Resistance in A. gambiae and A. aegypti Mosquitoes

Author(s) -

George Dimopoulos

Publication year - 2007

Publication title -

journal of visualized experiments

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.596

H-Index - 91

ISSN - 1940-087X

DOI - 10.3791/233

Subject(s) - malaria , dengue fever , anopheles gambiae , biology , aedes aegypti , virology , dengue virus , vector (molecular biology) , yellow fever , gene , anopheles , plasmodium falciparum , virus , genetics , immunology , ecology , larva , recombinant dna

In this interview, George Dimopoulos focuses on the physiological mechanisms used by mosquitoes to combat Plasmodium falciparum and dengue virus infections. Explanation is given for how key refractory genes, those genes conferring resistance to vector pathogens, are identified in the mosquito and how this knowledge can be used to generate transgenic mosquitoes that are unable to carry the malaria parasite or dengue virus.

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