Open AccessToxicological Characteristics Of N-Deacetyllappaconitine Under Chronic Administration In White Rats
Author(s) -
Lola Tishaevna Zakhidova,
Dilfuza Mir-Takhirovna Saidkhodjaeva,
Tolmas Tolibovich Khamroev,
Zafar Isomiddinovich Sanoev,
Visola Farmanovna Tukhtasheva,
Hilola Akhmedjanovna Rakhmanova
Publication year - 2021
Publication title -
the american journal of applied sciences
Language(s) - English
Resource type - Journals
ISSN - 2689-0992
DOI - 10.37547/tajas/volume03issue03-06
Subject(s) - medicine , pharmacology , traditional medicine , toxicology , biology
In chronic experiments in laboratory animals, studied toxicological perspective new antiarrhythmic effect of N-deacetyllappaconitine for the treatment of arrhythmic states, an original herbal preparation based on Aconitum leucostonum, Ac.Septentrionale was created. During 2,5 months of intragastric administration in animals exposed to all doses of N-deacetyllappaconitine, no deviations in the parameters of the functioning of the nervous system were found, therefore, this value is the lowest effective (threshold) dose in a chronic experiment.