ANTIDIABETIC ACTIVITY OF MANGIFERA INDICA ROOT IN ALLOXAN INDUCED DIABETES IN RATS

Diabetes mellitus is a chronic metabolic disease caused by an absolute or relative lack of insulin and or reduced insulin activity, which results in hyperglycemia and abnormalities in carbohydrate, protein and fat metabolism [1]. The presence of diabetes mellitus confers increased risk of many divesting complications such as cardiovascular diseases, peripheral vascular diseases [2], coronary artery diseases, stroke, neuropathy, renal failure, retinopathy amputations and blindness [3]. The main disadvantage of current drugs (biguanides, sulfonylureas) that they have to give throughout the life and produce side effects [5].