SIMULTANEOUS ESTIMATION OF CEFTAZIDINE AND AVIBACTUM IN TABLET DOSAGE FORM BY RP-HPLC

Ceftazidime chemically is 1-{ [(6R,7R)-7-[(2Z)-2-(2amino-1, 3-thiazol-4-yl) -2[(1-carboxy-1methylethoxy) imino] acetamido] -2carboxylato-8oxo-5-thia-1-azabicyclo [4. 2. 0] oct – 2 – en – 3 -yl] methyl} pyridin-1-ium the bactericidal activity of ceftazidime results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs) [1-2]. Avibactum chemically is sodium (2S, 5R)-2-carbamoyl-7-oxo-1, 6-diazabicyclo [3.2.1] octan-6-yl sulfate. Avibactam is a non-β lactam βlactamase inhibitor that inactivates some β-lactamases (Ambler class A β-lactamases, including Klebsiella pneumoniae carbapenemases. Ambler class C and some Ambler class D βlactamases) by a unique covalent and reversible mechanism, and protects ceftazidime from degradation by certain β-lactamases [3-4].