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150 Design and Optimization of High-dose Colon-targeted Controlled Drug Delivery System for Mesalamine using Eudragit Coated Matrix Tablets Venkata Radha Krishna Bodagala *, Narasimha Jayaveera Korlakunta , Sambasiva Rao Ambati 1 Department of Pharmaceutics, Sri Indu Institute of Pharmacy, Hyderabad-501510, Telangana, India. Department of Chemistry, Jawaharlal Nehru Technological University, Anantapur515001, Andhra Pradesh, India.