Simultaneous Estimation of Atorvastatin Calcium, Aspirin, Ramipril and Metoprolol Tartrate in Bulk and in its Capsule Formulation by First Order Derivative Spectrophotometry

Atorvastatin Calcium (ATR) is an oral anti-lipimic agent and chemically it is (βR, 8R)-2-(4-fluorophenyl)α, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-phenyl amino) carbonyl]-1H-pyrrole-1-heptanoic acid tri hydrate. Aspirin (ASP) is an oral Analgesic; anti pyretic; anti-inflammatory; anti-thrombotic agent and chemically it is 2-(Acetyloxy) benzoic acid. Ramipril (RAM) is an oral anti-hypertensive agent and chemically it is (2S.3aS.6aS) -1-[(S)-N-[(S)-1Carboxy-3phenyl propyl] alanyl] octahydro cyclopenta [b] pyrrole-carboxylic acid 1-ethyl ester. Metoprolol Tartrate (MET) is an oral Anti hypertensive; anti angina; anti arrhythmic agent and chemically it is (RS)-1-(isopropylamino)-3-p-(2methoxyethyl) phenoxypropan-2-ol (2R, 3R)-tartrate [1, 2] all the four drugs are official in IP [3] and The Extra Pharmacopeia [4]. ASP, RAM and MET are official in BP [5]. ASP and RAM are official in USP [6].