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Oral route of drug delivery is the feasible pathway of drug delivery because of easy administration, patient obedience and flexibility in the formulations. It is evident that novel drug delivery dosage forms are retained in the stomach for longer period of time that is existed in academic and industrial research groups. As different attempts has prepared to develop GRDDS. FDDStechnologybenefits drugs that have narrow window of assimilation in the stomach and upper GI tract and these systems remained in the stomach for hours and then progressively increase the GRT of the drugs [1, 2]. By this we can improve drug bio available nature, decreases wastage of drug and increases solubility of drugs which are low soluble in high pH environment. Floating drug delivery system is known as hydrodynamically balanced systems. It is having low bulk density that have sufficiently buoyancy to float over the gastric contents and remain buoyant in the gastric juice of the stomach without affecting gastric emptying rate for a prolonged period of time. This leads to an increased gastric retention time and a better control of the fluctuaions in plasma drug concentration. FDDS has density <1 that of gastric fluids which remains float in the stomach and doesn’t shows any affect on the GER for prolonged period of time. Hence the drug is released slowly from the system at desired level while Journal of Comprehensive Pharmacy

Design, development and In vitro characterization of Clopidogrel bisulfate floating drug delivery system