FORMULATION AND EVALUATION OF METFORMIN HYDROCHLORIDE SUSTAINED RELEASED MICROSPHERES

Microspheres have gained wide acceptance as a means to achieve oral and Parenteral controlled drug delivery systems. They often require a polymer as carrier as well as core material [1]. Among the various methods developed for the formulation of microspheres, the solvent evaporation method, ionic gelation method has gained much attention due to its ease of fabrication without compromising the activity of the drug. Metformin is an oral anti diabetic drug in the biguanide class. It is the first-line drug of choice for the treatment of type 2 diabetes, in particular, in overweight and obese people and those with normal kidney function. Its use in gestational diabetes has been limited by safety concerns. It is also used in the treatment of polycystic ovary syndrome, and has been investigated for other diseases where insulin resistance may be an important factor. Metformin improves hyperglycaemias primarily by suppressing glucose production by the liver (hepatic gluconeogenesis). The "average" person with type 2 diabetes has three times. Alginic acid is an anionic polysaccharide distributed widely in the cell walls of brown algae, where through binding with water it forms a viscous gum. In extracted form it absorbs water quickly; it is capable of absorbing 200-300 times its own weight in water. Diabetes mellitus (DM) is the name given to a group of disorders characterized by chronic hyperglycemia, polyurea, polydipsia, polyphagia, emaciation and weakness due to disturbance in carbohydrate, fat and protein metabolism associated with absolute or relative deficiency in insulin secretion and/or insulin action. A drug of choice, either alone or Journal of Comprehensive Pharmacy